Delayed granulomatous reaction to hyaluronic acid gel injection

Cutaneous granulomatous reaction to injectable hyaluronic acid gel.

Injectable hyaluronic acid (HA) derivatives are the most used reabsorbable dermal fillers for soft tissue augmentation today and their utilization is considered safe. We report a cutaneous granulomatous reaction that developed in a woman 5 weeks after the first treatment with a nonanimal HA derivative for the correction of facial wrinkling. We describe the clinicopathological findings and cours...

Eosinophilic granulomatous reaction after intradermal injection of hyaluronic acid.

Sir, Hyaluronic acid, one of the components of the extracellular matrix of dermis and other tissues, has natural hydrating functions with an ability to bind a large volume of water. It can be modified to form an insoluble, cross-linked, high viscosity gel whose dermal injection is suitable for the correction of soft tissue defects and the improvement of facial contouring. Dermal injection is ge...

Exudative granulomatous reaction to hyaluronic acid (Hylaform).

Immunological reaction after facial hyaluronic acid injection

We report two rare cases of inflammatory reactions with multiple subcutaneous facial painful collections after Hyaluronic acid injections, expose their management and discuss aetiologic hypothesis. Due to unfavourable evolution despite antibiotic treatment, surgical drainage was performed. Immune-mediated delayed hypersensitivity reactions were the most probable cause.

Cutaneous hypersensitivity reaction to injectable hyaluronic acid gel.

BACKGROUND Injectable hyaluronic acid gel is a non-animal biomaterial used for soft tissue augmentation. OBJECTIVE The dermal implantation of this naturally occurring polysaccharide is reported to be well tolerated by patients, with a longer duration in tissue than bovine collagen without any major local or systemic side effects. We report a case of an acute hypersensitivity reaction in a wom...